Does chamber design have any affect on a cylinder heads maximum CFM?
That's one of the reasons why big bore VW engines usually have higher outputs that stroker VW enginesYes.
For instance think about the valves, they sit in a recessed chamber, and they have one edge of the chamber up against one side of the valve, the other side is much more open. So the valve will flow more on the open side (towards the centre of the chamber) than the restricted side.
If you take a set of standard heads out to a larger bore, you can cut the side of the chamber back to give more breathing room round the tight side of the valve, allowing it to flow more.
So chamber design does influence gas flow.
Dave.